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Unravelling protein sorting

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Protein sorting to distinct plasma membrane domains in polarized epithelial cells is thought to occur in the Golgi complex, and to be mediated in part by lipid rafts. Now, analysis of protein trafficking in live cells has revealed unexpected sorting pathways that raise new questions about the specificity and sites of action of sorting mechanisms.

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Figure 1: Models for polarized sorting of membrane proteins in epithelial cells.
Figure 2: Effects of selective inhibition of vesicle delivery to the apical or basolateral membrane.

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Authors and Affiliations

  1. Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, 94305-5435, CA, USA

    W. James Nelson

  2. the Margaret M. Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, 10021, NY, USA

    Enrique Rodriguez-Boulan

Authors
  1. W. James Nelson
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  2. Enrique Rodriguez-Boulan
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Nelson, W., Rodriguez-Boulan, E. Unravelling protein sorting. Nat Cell Biol 6, 282–284 (2004). https://doi.org/10.1038/ncb0404-282

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