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A retention factor keeps death at bay

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Apoptosis is a carefully orchestrated series of events that allows cells to be eliminated without damaging their neighbours. Regulation is essential, as too much apoptosis can contribute to neurodegenerative disorders, whereas too little can result in cancer. Two reports in this issue now demonstrate that Ku70, a protein previously shown to function in DNA repair, has an important role in regulating apoptotic events.

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Figure 1: Activation of Bax in response to an apoptotic signal.

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Authors and Affiliations

  1. Division of Biological Sciences, University of Missouri, Columbia, 65211, MO, USA

    Steven F. Nothwehr

  2. Department of Cell Biology, University of Geneva,Quai Ernest-Ansermet 30, Geneva, CH1211, Geneva, 4, Switzerland

    Jean-Claude Martinou

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  1. Steven F. Nothwehr
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  2. Jean-Claude Martinou
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Correspondence to Jean-Claude Martinou.

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Nothwehr, S., Martinou, JC. A retention factor keeps death at bay. Nat Cell Biol 5, 281–282 (2003). https://doi.org/10.1038/ncb0403-281

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