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Cdc42 & GSK-3: signals at the crossroads

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Cell polarity is regulated by independent pathways that are controlled by Wnt- or Cdc42-mediated signalling. Now, glycogen synthase kinase 3 (GSK-3), an established component of the Wnt pathway, is shown to interact with Par6–protein kinase C ζ (PKCζ), a complex that transduces Cdc42 signals. This exciting result suggests a potential point of conversion between these previously distinct pathways.

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Figure 1: Polarization of migrating astrocytes.
Figure 2: Wnt signalling — a simplified scheme.

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Acknowledgements

A.J.H. is a Wellcome Senior Fellow; V.M.M.B. is a Medical Research Council Senior Research Fellow.

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Authors and Affiliations

  1. MRC Laboratory of Molecular Cell Biology & Department of Biology, University College London, Gower Street, London, WC1E 6BT

    Adrian Harwood

  2. Division of Biomedical Sciences, Cell and Molecular Biology Section, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, London

    Vania M. M. Braga

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  1. Adrian Harwood
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  2. Vania M. M. Braga
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Correspondence to Vania M. M. Braga.

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Harwood, A., Braga, V. Cdc42 & GSK-3: signals at the crossroads. Nat Cell Biol 5, 275–277 (2003). https://doi.org/10.1038/ncb0403-275

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