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Entosis: aneuploidy by invasion

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Aneuploidy is one of the most prevalent phenotypes of human tumours, but the underlying cause of this phenomenon remains highly debated. Entosis, the invasion of a living cell into another cell's cytoplasm, is now shown to perturb cytokinesis and induce the formation of aneuploid cells.

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Figure 1: Cytokinesis failure induced by entosis is a prelude to aneuploidy.

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Authors and Affiliations

  1. Aniek Janssen and René H. Medema are in the Department of Medical Oncology and Cancer Genomics Centre, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands. r.h.medema@umcutrecht.nl,

    Aniek Janssen & René H. Medema

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  1. Aniek Janssen
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  2. René H. Medema
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The authors declare no competing financial interests.

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Janssen, A., Medema, R. Entosis: aneuploidy by invasion. Nat Cell Biol 13, 199–201 (2011). https://doi.org/10.1038/ncb0311-199

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