Skip to main content
SpringerLink
Log in

Shortcuts to making cardiomyocytes

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

The adult human heart lacks sufficient regenerative capacity to recover after a myocardial infarction. Cell-based therapy has emerged as a potential treatment for the failing heart; however, a key issue for the success of future cell-based therapies is the ability to obtain patient-specific high-quality cardiomyocytes in a fast and efficient manner. Recent progress has been made towards this goal using reprogramming-based approaches.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Potential strategies to obtain exogenous cardiac cells for cell-based therapy.

References

  1. Laflamme, M. A. & Murry, C. E. Nat. Biotechnol. 23, 845–856 (2005).

    Article  CAS  Google Scholar 

  2. Hansson, E. M., Lindsay, M. E. & Chien, K. R. Cell Stem Cell 5, 364–377 (2009).

    Article  CAS  Google Scholar 

  3. Yi, B. A., Wernet, O. & Chien, K. R. J. Clin. Invest. 120, 20–28 (2010).

    Article  CAS  Google Scholar 

  4. Efe, J. A. et al. Nat. Cell Biol. 13, 215–222 (2011).

    Article  CAS  Google Scholar 

  5. Laflamme, M. A., Zbinden, S., Epstein, S. E. & Murry, C. E. Annu. Rev. Pathol. 2, 307–339 (2007).

    Article  CAS  Google Scholar 

  6. Yoshida, Y. & Yamanaka, S. J. Mol. Cell. Cardiol. 50, 327–332 (2011).

    Article  CAS  Google Scholar 

  7. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  8. Domian, I. J. et al. Science 326, 426–429 (2009).

    Article  CAS  Google Scholar 

  9. Qyang, Y. et al. Cell Stem Cell 1, 165–179 (2007).

    Article  CAS  Google Scholar 

  10. Moretti, A. et al. Cell 127, 1151–1165 (2006).

    Article  CAS  Google Scholar 

  11. Bu, L. et al. Nature 460, 113–117 (2009).

    Article  CAS  Google Scholar 

  12. Martin-Puig, S., Wang, Z. & Chien, K. R. Cell Stem Cell 2, 320–331 (2008).

    Article  CAS  Google Scholar 

  13. Braam, S. R., Passier, R. & Mummery, C. L. Trends Pharmacol. Sci. 30, 536–545 (2009).

    Article  CAS  Google Scholar 

  14. Szabo, E. et al. Nature 468, 521–526 (2010).

    Article  CAS  Google Scholar 

  15. Ieda, M. et al. Cell 142, 375–386 (2010).

    Article  CAS  Google Scholar 

  16. Laugwitz, K. L. et al. Nature 433, 647–653 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Stem Cell and Regenerative Biology, Huansheng Xu, B. Alexander Yi, Kenneth R. Chien are in the Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA and the Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA. krchien@partners.org,

    Huansheng Xu, B. Alexander Yi & Kenneth R. Chien

Authors
  1. Huansheng Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Alexander Yi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kenneth R. Chien
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Xu, H., Yi, B. & Chien, K. Shortcuts to making cardiomyocytes. Nat Cell Biol 13, 191–193 (2011). https://doi.org/10.1038/ncb0311-191

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0311-191

  • Springer Nature Limited

Search

Navigation