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How to grow a bud: an importin acts in asymmetric division

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The growth of daughter cells in budding yeast is a classic model for investigating mechanisms involved in asymmetric cell division. An unexpected collaboration between the DEAD-box protein Dbp5 and the nuclear transport receptor Kap104 controls localized protein synthesis at the bud tip during mitosis.

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Figure 1: mRNA export and remodelling station at the cytoplasmic face of the NPC.
Figure 2: Kap104 might play either a direct or indirect role in removing translational repressors at the bud tip.

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  1. David S. Goldfarb is in the Department of Biology, University of Rochester, Rochester, NY 14627, USA. dasg@mail.rochester.edu,

    David S. Goldfarb

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  1. David S. Goldfarb
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Goldfarb, D. How to grow a bud: an importin acts in asymmetric division. Nat Cell Biol 11, 243–245 (2009). https://doi.org/10.1038/ncb0309-243

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