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How APC/C orders destruction

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The anaphase-promoting complex/cyclosome (APC/C) is a ubiquitin ligase that controls cell-cycle progression by targeting proteins for destruction by the 26S proteasome. The APC/C is active throughout late mitosis and G1 phase but APC/C substrates are degraded in a specific order. A recent study provides insights into how ordered turnover of substrates is achieved.

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Figure 1: Preferential ubiquitination of processive substrates by APC/CCdh1 results in earlier degradation in late mitosis and G1.
Figure 2: A model for substrate recognition by APC/C and Cdh1.

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Authors and Affiliations

  1. the Research Institute of Molecular Pathology (IMP), Vienna, 1030, Austria

    Bettina A. Buschhorn & Jan-Michael Peters

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  1. Bettina A. Buschhorn
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  2. Jan-Michael Peters
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Buschhorn, B., Peters, JM. How APC/C orders destruction. Nat Cell Biol 8, 209–211 (2006). https://doi.org/10.1038/ncb0306-209

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