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Heads or tails: can Wnt tell which one is up?

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Planarian flatworms regenerate their heads and tails after amputation. It turns out that they use Wnt–β-catenin signalling to determine where the head and the tail should form.

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Figure 1: Wnt–β-catenin signalling regulates head and tail formation during planarian regeneration and vertebrate embryogenesis.

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Authors and Affiliations

  1. Elly M. Tanaka is at the Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Dresden, Germany and the Center for Regenerative Therapies, Dresden. Gilbert Weidinger is at the Biotechnology Center of the Technical University Dresden, Tatzberg 47, D-01307 Dresden, Germany. tanaka@mpi-cbg.de gilbert.weidinger@biotec.tu-dresden.de,

    Elly M. Tanaka & Gilbert Weidinger

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  1. Elly M. Tanaka
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  2. Gilbert Weidinger
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Tanaka, E., Weidinger, G. Heads or tails: can Wnt tell which one is up?. Nat Cell Biol 10, 122–124 (2008). https://doi.org/10.1038/ncb0208-122

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