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TRPs as mechanosensitive channels

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Mechanosensitive channels are essential for effective cellular function, but elucidation of their molecular identity and mechanisms of activation has proven difficult. Two recent studies now implicate members of the transient receptor potential (TRP) family as components of the mechanosensitive channels in vertebrate hair cells (TRPA1) and stretch-activated channels (TRPC1) in several different vertebrate cell types.

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Figure 1: A schematic representation of TRPA1 and TRPC1 acting as mechanosensitive channels showing their hypothesized different mechanisms of activation.

References

  1. Sukharev, S. & Corey, D. P. Science's STKE 219, re4 (2004).

    Google Scholar 

  2. Corey, D. P. et al. Nature 10.1038/nature03066 (2004).

  3. Maroto, R. et al. Nature Cell Biol. 7, 179–185 (2005).

    Article  CAS  Google Scholar 

  4. Clapham, D. E. Nature 426, 517–524 (2003).

    Article  CAS  Google Scholar 

  5. Nilius, B. Science's STKE 243, pe36 (2004).

    Google Scholar 

  6. Story, G. M. et al. Cell 112, 819–829 (2003).

    Article  CAS  Google Scholar 

  7. Jordt, S. -E. et al. Nature 427, 260–265 (2004).

    Article  CAS  Google Scholar 

  8. Christensen, O. Nature 330, 66–68 (1987).

    Article  CAS  Google Scholar 

  9. Wes, P. D. et al. Proc. Natl Acad. Sci. USA 92, 9652–9656 (1995).

    Article  CAS  Google Scholar 

  10. Hamill, O. P. & Martinac, B. Physiol. Revs 81, 685–740 (2001).

    Article  CAS  Google Scholar 

  11. Voets, T. et al. Nature 430, 748–754 (2004).

    Article  CAS  Google Scholar 

  12. Rosado, J. A. & Sage, S. O. Biochem. J. 356, 191–198 (2001).

    Article  CAS  Google Scholar 

  13. Vaca, L. & Sampieri, A. J. Biol. Chem. 277, 42178–42187 (2002).

    Article  CAS  Google Scholar 

  14. Mori, T. et al. J. Exp. Med. 195, 673–681 (2002).

    Article  CAS  Google Scholar 

  15. Chen, J. & Barritt, G. J. Biochem. J. 373, 327–336 (2003).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Medical Biochemistry, School of Medicine, Faculty of Health Sciences, Flinders University, GPO Box 2100, Adelaide, 5001, SA, Australia

    Greg Barritt

  2. Department of Physiology, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, 5005, SA, Australia

    Grigori Rychkov

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  1. Greg Barritt
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  2. Grigori Rychkov
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Barritt, G., Rychkov, G. TRPs as mechanosensitive channels. Nat Cell Biol 7, 105–107 (2005). https://doi.org/10.1038/ncb0205-105

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