Specific gene expression patterns must be tightly regulated for eukaryotic cells to acquire unique structural and functional features. A key step is transcriptional initiation, during which epigenetic activators are thought to facilitate the process by establishing and maintaining transcription-competent chromatin structures. Accumulating evidence shows that an epigenetic regulator can also control the next step — transcriptional elongation.
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Sanchez-Elsner, T., Sauer, F. The heat is on with TAC1. Nat Cell Biol 6, 92–93 (2004). https://doi.org/10.1038/ncb0204-92
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DOI: https://doi.org/10.1038/ncb0204-92
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