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'Rab'ing up endosomal membrane transport

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Early endosomes are the first sorting station from which endocytosed materials are targeted to various intracellular destinations. Recent work has identified the FYVE-domain protein rabenosyn-5 as a bifunctional effector of the GTPases rab5 and rab4, physically connecting entry and recycling sites on early endosomes.

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Figure 1
Figure 2: Proposed model for the bivalent effector function of rabenosyn-5 connecting rab5 and rab4 domains on early endosomes.

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Authors and Affiliations

  1. Department of Cell Biology and Institute of Biomembranes, University Medical Center, CX, 3584, Utrecht, The Netherlands

    Magda Deneka & Peter van der Sluijs

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  1. Magda Deneka
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  2. Peter van der Sluijs
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Deneka, M., van der Sluijs, P. 'Rab'ing up endosomal membrane transport. Nat Cell Biol 4, E33–E35 (2002). https://doi.org/10.1038/ncb0202-e33

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