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Myc and a Cdk2 senescence switch

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Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.

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Figure 1: Cdk2 is a suppressor of Myc-induced cellular senescence.
Figure 2: c-Myc and Cdk2 control a senescence switch that may be important for both tumorigenesis and oncogene addiction.

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Authors and Affiliations

  1. Jan van Riggelen and Dean W. Felsher are in the Division of Oncology, Departments of Medicine, Pathology and Molecular Imaging, Stanford University School of Medicine, Stanford University, CA 94305-5151, USA. dfelsher@stanford.edu,

    Jan van Riggelen & Dean W. Felsher

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  1. Jan van Riggelen
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  2. Dean W. Felsher
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van Riggelen, J., Felsher, D. Myc and a Cdk2 senescence switch. Nat Cell Biol 12, 7–9 (2010). https://doi.org/10.1038/ncb0110-7

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