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Two Rabs for exosome release

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Exosomes are endosome-derived membrane vesicles that are key for intercellular communication in the immune system and elsewhere. Rab27A and Rab27B GTPases and two of their cognate effector proteins seem to be needed to drive the physiologically important exosome-release process in certain cell types.

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Figure 1: A role for Rab27A and Rab27B and their effectors in exosome secretion.

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  1. Suzanne Pfeffer is at the Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive B400, Stanford, 94305-5307, CA, USA

    Suzanne R. Pfeffer

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  1. Suzanne R. Pfeffer
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Pfeffer, S. Two Rabs for exosome release. Nat Cell Biol 12, 3–4 (2010). https://doi.org/10.1038/ncb0110-3

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