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Hearing the messenger: Ins(1,4,5)P3 and deafness

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Genetic studies have conclusively linked connexin channels to human diseases, but the nature of the signals that are disrupted by channel mutations has remained elusive. A recent study has taken advantage of a deafness-causing mutation to suggest that permeability to inositol trisphosphate, the Ca2+-mobilizing messenger, is crucial for normal hearing.

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Figure 1: Proposed role of Ins(1,4,5)P3 propagation through connexin channels in auditory transduction.

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Authors and Affiliations

  1. Department of Neuroscience, Institut Pasteur, Paris, 75015, France

    Roberto Bruzzone & Martine Cohen-Salmon

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  1. Roberto Bruzzone
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  2. Martine Cohen-Salmon
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Bruzzone, R., Cohen-Salmon, M. Hearing the messenger: Ins(1,4,5)P3 and deafness. Nat Cell Biol 7, 14–16 (2005). https://doi.org/10.1038/ncb0105-14

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