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Defying death: showing Bcl-2 the way home

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Bcl-2 and Bcl-xL perform important functions in cell life or death decisions by setting the threshold for activation of the programmed cell death machinery. FKBP38, a member of the immunophilin family, has now been identified as a new Bcl-2/Bcl-xL-binding partner. Furthermore, FKBP38 seems to be crucial in targeting Bcl-2/Bcl-xL to the correct cellular locations.

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Figure 1: The mitochondrial apoptosome route to apoptosis.
Figure 2

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  1. Department of Genetics, Molecular Cell Biology Laboratory, Trinity College, Dublin, Ireland

    Colin Adrain, Emma M. Creagh & Seamus J. Martin

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  1. Colin Adrain
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  2. Emma M. Creagh
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  3. Seamus J. Martin
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Adrain, C., Creagh, E. & Martin, S. Defying death: showing Bcl-2 the way home. Nat Cell Biol 5, 9–11 (2003). https://doi.org/10.1038/ncb0103-9a

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