Skip to main content
SpringerLink
Log in

A crossbridge too far

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Myosin V is a marvellous molecular motor that delivers various cargo to specific addresses in eukaryotic cells. Recent developments are leading to a detailed molecular understanding of how this enzyme transduces the chemical energy of ATP hydrolysis into mechanical movement along actin filaments.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2: Two current working hypotheses for nucleotide-dependent coupling of myosin V stepping.

References

  1. Mehta, A. D. et al. Nature 400, 590–593 (1999).

    Article  CAS  Google Scholar 

  2. Sakamoto, T., Amitani, I., Yokota, E. & Ando, T. Biochem. Biophys. Res. Commun. 272, 586–590 (2000).

    Article  CAS  Google Scholar 

  3. Rief, M. et al. Proc. Natl Acad. Sci. USA 97, 9482–9486 (2000).

    Article  CAS  Google Scholar 

  4. Veigel, C., Wang, F., Bartoo, M. L., Sellers, J. R. & Molloy, J. E. Nature Cell Biol. 4, 59–65 (2002).

    Article  CAS  Google Scholar 

  5. Svoboda, K., Schmidt, C. F., Schnapp, B. J. & Block, S. M. Nature 365, 721–727 (1993).

    Article  CAS  Google Scholar 

  6. Finer, J. T., Simmons, R. M. & Spudich, J. A. Nature 368, 113–119 (1994).

    Article  CAS  Google Scholar 

  7. Vale, R. D. et al. Nature 380, 451–453 (1996).

    Article  CAS  Google Scholar 

  8. Noji, H., Yasuda, R., Yoshida, M. & Kinosita, K. Jr, Nature 386, 299–302 (1997).

    Article  CAS  Google Scholar 

  9. Wells, A. L. et al. Myosin VI is an actin-based motor that moves backwards. Nature 401, 505–508 (1999).

    Article  CAS  Google Scholar 

  10. Spudich, J. A. The myosin swinging cross-bridge model. Nature Rev. Mol. Cell Biol. 2, 387–392 (2001).

    Article  CAS  Google Scholar 

  11. De La Cruz, E. M., Wells, A. L., Rosenfeld, S. S., Ostap, E. M. & Sweeney, H. L. Proc. Natl Acad. Sci. USA 96, 13726–13731 (1999).

    Article  CAS  Google Scholar 

  12. Moore, J. R., Krementsova, E. B., Trybus, K. M. & Warshaw, D. M. J. Cell Biol. 155, 625–635 (2001).

    Article  CAS  Google Scholar 

  13. Rice, S. et al. Nature 402, 778–784 (1999).

    Article  CAS  Google Scholar 

  14. Rock, R. S. et al. Proc. Natl Acad. Sci. USA 98, 13655–13659 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Stanford University School of Medicine, Stanford, 94305, California, USA

    James A. Spudich & Ronald S. Rock

Authors
  1. James A. Spudich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ronald S. Rock
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spudich, J., Rock, R. A crossbridge too far. Nat Cell Biol 4, E8–E10 (2002). https://doi.org/10.1038/ncb0102-e8

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0102-e8

  • Springer Nature Limited

This article is cited by

Search

Navigation