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Strabismus comes into focus

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At least one member of the Frizzled (Fz) family of receptors, together with the downstream signalling protein Dishevelled, participates in several distinct, yet closely related signal transduction pathways. Activation of the correct signal transduction pathway is critical. Here, a new study suggests that the transmembrane protein Strabismus participates in this decision.

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Figure 1: Two alternative Wnt signalling pathways.
Figure 2: Planar cell polarity and convergent extension.

References

  1. Park, M. & Moon, R. T. Nature Cell Biol. 4, 20–25 (2001).

    Article  Google Scholar 

  2. Shulman, J. M., Perrimon, N. & Axelrod, J. D. Trends Genet. 14, 452–458 (1998).

    Article  CAS  PubMed  Google Scholar 

  3. Miller, J. R., Hocking, A. M., Brown, J. D. & Moon, R. T. Oncogene 18, 7860–7872 (1999).

    Article  CAS  PubMed  Google Scholar 

  4. Wehrli, M. et al. Nature 407, 527–530 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. Boutros, M., Paricio, N. P., Strutt, D. I. & Mlodzik, M. Cell 94, 109–118 (1998).

    Article  CAS  PubMed  Google Scholar 

  6. Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T. & Perrimon, N. Genes Dev. 12, 2610–2622 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Heisenberg, C. P. et al. Nature 405, 76–81 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Tada, M. & Smith, J. C. Development 127, 2227–2238 (2000).

    CAS  PubMed  Google Scholar 

  9. Djiane, A., Riou, J., Umbhauer, M., Boucaut, J. & Shi, D. Development 127, 3091–3100 (2000).

    CAS  PubMed  Google Scholar 

  10. Rothbacher, U. et al. EMBO J. 19, 1010–1022 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Wallingford, J. B. et al. Nature 405, 81–85 (2000).

    Article  CAS  PubMed  Google Scholar 

  12. Axelrod, J. D. Genes Dev. 15, 1182–1187 (2001).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Wolff, T. & Rubin, G. M. Development 125, 1149–1159 (1998).

    CAS  PubMed  Google Scholar 

  14. Taylor, J., Abramova, N., Charlton, J. & Adler, P. N. Genetics 150, 199–210 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Peters, J. M., McKay, R. M., McKay, J. P. & Graff, J. M. Nature 401, 345–350 (1999).

    Article  CAS  PubMed  Google Scholar 

  16. McKay, R. M., Peters, J. M. & Graff, J. M. Dev. Biol. 235, 378–387 (2001).

    Article  CAS  PubMed  Google Scholar 

  17. Rousset, R. et al. Genes Dev. 15, 658–671 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Yan, D. et al. Proc. Natl Acad. Sci. USA 98, 3802–3807 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Wallingford, J. B. & Harland, R. M. Development 128, 2581–2592 (2001).

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, CA 94305-5324, Stanford, USA

    Jeffrey D. Axelrod

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  1. Jeffrey D. Axelrod
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Axelrod, J. Strabismus comes into focus. Nat Cell Biol 4, E6–E8 (2002). https://doi.org/10.1038/ncb0102-e6

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