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Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device

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Abstract

Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.

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Figure 1: Images of the microchip reservoirs and implantable drug delivery system.
Figure 2: Summary of in vivo results.

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Acknowledgements

We thank Zouhair Sbiaa and Michael Finot (Micralyne) for producing the microchips used in this study, and all members of the MicroCHIPS team, past and present, who participated in developing this technology and in the practical demonstration of its utility in vivo.

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Author notes

  1. James H Prescott and Sara Lipka: These authors contributed equally to this work.

Authors and Affiliations

  1. MicroCHIPS Inc., 6-B Preston Court, Bedford, 01730, Massachusetts, USA

    James H Prescott, Sara Lipka, Samuel Baldwin, Norman F Sheppard Jr., John M Maloney, Jonathan Coppeta, Barry Yomtov, Mark A Staples & John T Santini Jr.

Authors
  1. James H Prescott
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  2. Sara Lipka
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  3. Samuel Baldwin
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  4. Norman F Sheppard Jr.
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  5. John M Maloney
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  6. Jonathan Coppeta
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  7. Barry Yomtov
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  8. Mark A Staples
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  9. John T Santini Jr.
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Corresponding author

Correspondence to John T Santini Jr..

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Competing interests

The authors are current or former employees of MicroCHIPS, Inc. and possess stock or stock options in MicroChips, Inc.

Supplementary information

Supplementary Fig. 1

In vitro leuprolide release kinetics. (PDF 14 kb)

Supplementary Methods (PDF 27 kb)

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Prescott, J., Lipka, S., Baldwin, S. et al. Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device. Nat Biotechnol 24, 437–438 (2006). https://doi.org/10.1038/nbt1199

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  • DOI: https://doi.org/10.1038/nbt1199

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