Cultured cambial meristematic cells could enable large-scale production of certain natural products.
References
Mann, J. Nat. Rev. Cancer 2, 143–148 (2002).
Koehn, F.E. & Carter, G.T. Nat. Rev. Drug Discov. 4, 206–220 (2005).
Lee, E.-K. et al. Nat. Biotechnol. 28, 1213–1217 (2010).
Roberts, S.C. Nat. Chem. Biol. 3, 387–395 (2007).
Kolewe, M.E., Gaurav, V. & Roberts, S.C. Mol. Pharm. 5, 243–256 (2008).
Ajikumar, P.K. et al. Science 330, 70–74 (2010).
Keasling, J.D. ACS Chem. Biol. 3, 64–76 (2008).
Naill, M.C. & Roberts, S.C. Biotechnol. Bioeng. 90, 491–500 (2005).
Bringi, V., Kadkade, P.G., Prince, C.L. & Roach, B.L. US patent 7264951 (2007).
Leonard, E., Runguphan, W., O'Connor, S. & Prather, K.J. Nat. Chem. Biol. 5, 292–300 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Roberts, S., Kolewe, M. Plant natural products from cultured multipotent cells. Nat Biotechnol 28, 1175–1176 (2010). https://doi.org/10.1038/nbt1110-1175
Published:
Issue Date:
DOI: https://doi.org/10.1038/nbt1110-1175
- Springer Nature America, Inc.
This article is cited by
-
A novel strategy to enhance terpenoids production using cambial meristematic cells of Tripterygium wilfordii Hook. f.
Plant Methods (2019)
-
Callus of East Indian sandalwood co-cultured with fungus Colletotrichum gloeosporioides accumulates santalenes and bisabolene
Trees (2019)
-
Squalene production in the cell suspension cultures of Indian sandalwood (Santalum album L.) in shake flasks and air lift bioreactor
Plant Cell, Tissue and Organ Culture (PCTOC) (2018)
-
In vitro plant tissue culture: means for production of biological active compounds
Planta (2018)
-
High taxonomic diversity of cultivation-recalcitrant endophytic bacteria in grapevine field shoots, their in vitro introduction, and unsuspected persistence
Planta (2017)