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Engineering better cytokines

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Designing enzymes with protective shells that are cleaved once they arrive at inflammatory sites can be used to enhance immune therapy.

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Figure 1: A protecting shell, often called a latency peptide, is spliced onto a gene encoding a cytokine.

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Steinman, L. Engineering better cytokines. Nat Biotechnol 21, 1293–1294 (2003). https://doi.org/10.1038/nbt1103-1293

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