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Simple recipe for blocking ion channels

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Ion channels can be inshibited by polyclonal antibodies targeted to a specific extracellular loop.

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Figure 1: E3 targeting of six-transmembrane-domain ion channels.

Bob Crimi

References

  1. Xu, S.-H. et al. Nat. Biotechnol. 23, 1289–1293 (2005).

    Article  CAS  Google Scholar 

  2. Dallas, M. Deuchars, S.A. & Deuchars, J.J. Neurosci. Methods 146, 133–148 (2005)

    Article  CAS  Google Scholar 

  3. Choe, S. Nat. Rev. Neurosci. 3, 115–121 (2002).

    Article  CAS  Google Scholar 

  4. Beech, D.J. Clin Exp Pharmacol Physiol. 2005 32(8): 597–603 (2005)

    Article  Google Scholar 

  5. Zhou, B.Y., Ma, W. & Huang, X.Y. J. Gen. Physiol. 111, 555–563 (1998).

    Article  CAS  Google Scholar 

  6. Xu S.Z. & Beech, D.J. Circ. Res. 88, 84–87, (2001).

    Article  CAS  Google Scholar 

  7. Rosado, J.A. Brownlow, S.L. & Sage, S.O. J. Biol. Chem. 277, 42157–42163 (2002)

    Article  CAS  Google Scholar 

  8. Clapham, D. Nature 426, 517–524 (2003).

    Article  CAS  Google Scholar 

  9. Guderman, T. & Flockerzi, V. Naunyn-Schmied. Arch. Pharm. 371, 325–333 (2005).

    Article  Google Scholar 

  10. Rami, H.K. et al. Bioorg. & Med. Chem. Lett. 14, 3631–3634 (2004).

    Article  CAS  Google Scholar 

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Benham, C. Simple recipe for blocking ion channels. Nat Biotechnol 23, 1234–1235 (2005). https://doi.org/10.1038/nbt1005-1234

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