Skip to main content
SpringerLink
Log in

Phasing in iodine for structure determination

  • News & Views
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

A new method for solving X-ray crystal structures relies on the introduction of iodine into proteins in the form of p-iodophenylalanine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Scheme of the method in Xie et al.

Bob Crimi

References

  1. Xie, J., Wang, L., Brock, A., Spraggon, G. & Schultz, P.G. Nat. Biotechnol. 22, XX–XX (2004).

    Article  Google Scholar 

  2. Blundell, T.L. & Johnson, L.N. Protein Crystallography (Academic Press, New York, 1976).

    Google Scholar 

  3. Hendrickson, W.A. J. Synchrotron Rad. 6, 845–851 (1997).

    Article  Google Scholar 

  4. Sigler, P.B. Biochemistry 9, 3609–3617 (1970).

    Article  CAS  Google Scholar 

  5. Brzozowski, A.M. et al. Nature 351, 491–494 (1991).

    Article  CAS  Google Scholar 

  6. Dauter, Z., Dauter, M. & Rajashankar, K.R. Acta Crystallogr. D56, 232–237 (2000).

    CAS  Google Scholar 

  7. Wang, L., Brock, A., Herberich, B. & Schultz, P.G. Science 292, 498–500 (2001).

    Article  CAS  Google Scholar 

  8. Chin, J.W. et al. Science 301, 964–967 (2003).

    Article  CAS  Google Scholar 

  9. Ravelli, R.B.G. & McSweeney, S.M. Structure 8, 315–328 (2000).

    Article  CAS  Google Scholar 

  10. Zwart, P.H., Banumathi, S., Dauter, M. & Dauter, Z. Acta Crystallogr., in press (2004).

Download references

Author information

Authors and Affiliations

  1. the Synchrotron Radiation Research Section of the National Cancer Institute, Brookhaven National Laboratory, Bldg 725A, Upton, 11973, New York, USA

    Zbigniew Dauter

Authors
  1. Zbigniew Dauter
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dauter, Z. Phasing in iodine for structure determination. Nat Biotechnol 22, 1239–1240 (2004). https://doi.org/10.1038/nbt1004-1239

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1004-1239

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation