Skip to main content

Advertisement

Log in

Seeking sweet relief for diabetes

  • Feature
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

An Erratum to this article was published on 01 February 2003

Diabetes is a modern-day epidemic in the making, but drug developers are still undecided over the best strategy for its treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: The disturbing face of diabetes.
Figure 2: Targets for treatments for type 2 diabetes.

References

  1. Data taken from US Centers for Disease Control web site, http://www.cdc.gov/diabetes.

  2. American Diabetes Association. Economic consequences of diabetes mellitus in the US in 1997. Diabetes Care 21, 296–309 (1998).

  3. Knowler, W.C. et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346, 393–403 (2002).

    Article  CAS  Google Scholar 

  4. Barroso, I. et al. Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402, 880–883 (1999).

    Article  CAS  Google Scholar 

  5. Fletcher, L. Oral insulin deal for Nobex. Nat. Biotechnol. 20, 645 (2002).

  6. Steppan, C.M. et al. The hormone resistin links obesity to diabetes. Nature 409, 307–312 (2002).

    Article  Google Scholar 

  7. Sesti, G. Searching for type 2 diabetes genes: prospects in pharmacotherapy. Pharmacogenomics J. 2, 25–29 (2002).

    Article  CAS  Google Scholar 

  8. Lumelsky, N. et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292, 1389–1394 (2001).

    Article  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dove, A. Seeking sweet relief for diabetes. Nat Biotechnol 20, 977–981 (2002). https://doi.org/10.1038/nbt1002-977

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1002-977

  • Springer Nature America, Inc.

This article is cited by

Navigation