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Combinatorics and next-generation sequencing

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The massive capacity of today's sequencing machines can be harnessed efficiently by sequencing pooled samples and decoding the results.

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Figure 1: Pooling samples using a combinatorial design.

Katie Vicari

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Authors and Affiliations

  1. Nick Patterson and Stacey Gabriel are at the Broad Institute, Cambridge, Massachusetts, USA.,

    Nick Patterson & Stacey Gabriel

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  1. Nick Patterson
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  2. Stacey Gabriel
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Correspondence to Nick Patterson.

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Patterson, N., Gabriel, S. Combinatorics and next-generation sequencing. Nat Biotechnol 27, 826–827 (2009). https://doi.org/10.1038/nbt0909-826

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