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A framework for the use of genomics data at the EPA

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The US Environmental Protection Agency is developing a new guidance that outlines best practice in the submission, quality assurance, analysis and management of genomics data for environmental applications.

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Figure 1: Genomics, proteomics and metabonomics/metabolomics can provide useful weight-of-evidence data along the source-to-outcome continuum when appropriate bioinformatic and computational methods are applied toward integrating molecular, chemical and toxicological information.

References

  1. US Environmental Protection Agency. Potential Implications of Genomics for Regulatory and Risk Assessment Applications at EPA. Science Policy Council. EPA Publication No EPA 100/B-04/002 (EPA, Washington, DC, 2004). http://www.epa.gov/osa/genomics.htm

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  5. Dearfield, K.L., Benson, W.H., Gallagher, K. & Johnson, J. in Genetics and Environmental Policy: Ethical, Legal and Regulatory Perspectives. (ed. Marchant, G.), in press (Johns Hopkins University Press, Baltimore, 2007).

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Acknowledgements

This perspective is based on the efforts of the dedicated EPA staff within the Office of the Science Advisor, the Science Policy Council, the Agency-wide Genomics Task Force and the subsequent Genomics Technical Framework Workgroups.

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Authors and Affiliations

  1. Office of Research and Development, US Environmental Protection Agency, National Center for Computational Toxicology (D343-03), Research Triangle Park, 27711, North Carolina, USA

    David J Dix

  2. US Department of Agriculture, Food Safety and Inspection Service,

    Kathryn Gallagher, Kerry L Dearfield & William H Farland

  3. Office of the Science Advisor (8105R), US Environmental Protection Agency, Ariel Rios Building, 1200 Pennsylvania Avenue, NW, DC 20460, Washington, USA

    Kathryn Gallagher, Kerry L Dearfield & William H Farland

  4. Gulf Ecology Division, Office of Research and Development, US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Sabine Island Drive, Gulf Breeze, 32561, Florida, USA

    William H Benson

  5. US Environmental Protection Agency, Region 7, 901 North 5th Street, Kansas City, 66101, Kansas, USA

    Brenda L Groskinsky

  6. Office of Prevention Pesticides Toxic Substances, US Environmental Protection Agency, MC 7101M, 1200 Pennsylvania Avenue, NW, DC 20460, Washington, USA

    J Thomas McClintock

Authors
  1. David J Dix
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  2. Kathryn Gallagher
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  3. William H Benson
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  4. Brenda L Groskinsky
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  5. J Thomas McClintock
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  6. Kerry L Dearfield
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  7. William H Farland
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Corresponding author

Correspondence to David J Dix.

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Dix, D., Gallagher, K., Benson, W. et al. A framework for the use of genomics data at the EPA. Nat Biotechnol 24, 1108–1111 (2006). https://doi.org/10.1038/nbt0906-1108

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  • DOI: https://doi.org/10.1038/nbt0906-1108

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