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RNA as the catalyst for drug screening

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Reporter ribozymes that allow monitoring of protein–nucleic acid and protein–protein interactions facilitate rapid identification of inhibitors for use in drug discovery.

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Figure 1: Reporting interactions between proteins and various capture reagents.

© Bob Crimi

References

  1. Ellington, A.D. & Szostak, J.W. Nature 346, 818–822 (1990).

    Article  CAS  Google Scholar 

  2. Tuerk, C. & Gold, L. Science 249, 505–510 (1990).

    Article  CAS  Google Scholar 

  3. Eaton, B.E., Gold, L. & Zichi, D.A. Chem. Biol. 2, 633–638 (1995).

    Article  CAS  Google Scholar 

  4. Ellington, A.D. & Conrad, R. Biotechnol. Annu. Rev. 1, 185–214 (1995)

    Article  CAS  Google Scholar 

  5. Hartig J.S. et al. Nat. Biotechnol. 20, 717–722 (2002).

    Article  CAS  Google Scholar 

  6. Seetharaman, S., Zivarts, M., Sudarsan, N. & Breaker, R.R. Nat. Biotechnol. 19, 336–341 (2001).

    Article  CAS  Google Scholar 

  7. Robertson, M.P. & Ellington, A.D. Nucleic Acids Res. 28, 1751–1759 (2000).

    Article  CAS  Google Scholar 

  8. Hesselberth, J., Robertson, M.P., Jhaveri, S. & Ellington, A.D. J. Biotechnol. 74, 15–25 (2000).

    CAS  PubMed  Google Scholar 

  9. Green, L.S., Bell, C. & Janjic, N. Aptamers as reagents for high throughput screening. BioTechniques 30, 1094–1110 (2001).

    Article  CAS  Google Scholar 

  10. Fredriksson, S. et al. Nat. Biotechnol. 20, 473–477 (2002).

    Article  CAS  Google Scholar 

  11. Petach, H. & Gold, L. Curr. Opin. Biotechnol., in press (2002).

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Gold, L. RNA as the catalyst for drug screening. Nat Biotechnol 20, 671–672 (2002). https://doi.org/10.1038/nbt0702-671

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