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Next-generation biomarkers for detecting kidney toxicity

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There is a paucity of biomarkers that reliably detect nephrotoxicity. The Predictive Safety Testing Consortium (PSTC) faced several challenges in identifying novel safety biomarkers in the renal setting.

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Figure 1: The utility of biomarkers to detect injury to specific nephron segments affected by various nephrotoxicants.

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Authors and Affiliations

  1. Joseph V. Bonventre and Vishal S. Vaidya are in the Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA;,

    Joseph V Bonventre & Vishal S Vaidya

  2. Robert Schmouder is in Translational Sciences, Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA;,

    Robert Schmouder

  3. Peter Feig is in Cardiovascular Clinical Research, Merck Research Laboratories, Rahway, New Jersey, USA;,

    Peter Feig

  4. Frank Dieterle is in Translational Sciences, Novartis Institutes for BioMedical Research, Basel, Switzerland.,

    Frank Dieterle

Authors
  1. Joseph V Bonventre
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  2. Vishal S Vaidya
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  3. Robert Schmouder
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  4. Peter Feig
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  5. Frank Dieterle
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Corresponding author

Correspondence to Joseph V Bonventre.

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Competing interests

R.S. and F.D. are employees of Novartis and P.F. is an employee of Merck.

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Bonventre, J., Vaidya, V., Schmouder, R. et al. Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol 28, 436–440 (2010). https://doi.org/10.1038/nbt0510-436

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