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The oldest antibodies newly discovered

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Lamprey monoclonal antibodies provide stable and high-avidity alternatives to immunoglobulins.

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Figure 1: Assembly of lamprey variable lymphocyte receptors (VLRs), compared with the V(D)J-rearrangement that gives rise to mammalian antibodies.

References

  1. Binz, H.K., Amstutz, P. & Plückthun, A. Nat. Biotechnol. 23, 1257–1268 (2005).

    Article  CAS  Google Scholar 

  2. Pancer, Z. et al. Nature 430, 174–180 (2004).

    Article  CAS  Google Scholar 

  3. Herrin, B.R. et al. Proc. Natl. Acad. Sci. USA 105, 2040–2045 (2008).

    Article  CAS  Google Scholar 

  4. Kim, H.M. et al. J. Biol. Chem. 282, 6726–6732 (2007).

    Article  CAS  Google Scholar 

  5. Pancer, Z. & Cooper, M.D. Annu. Rev. Immunol. 24, 497–518 (2006).

    Article  CAS  Google Scholar 

  6. Alder, M.N. et al. Science 310, 1970–1973 (2005).

    Article  CAS  Google Scholar 

  7. Rogozin, I.B. et al. Nat. Immunol. 8, 647–656 (2007).

    Article  CAS  Google Scholar 

  8. Alder, M.N. et al. Nat. Immunol. 9, 319–327 (2008).

    Article  CAS  Google Scholar 

  9. Flajnik, M.F. Nat. Rev. Immunol. 2, 688–698 (2002).

    Article  CAS  Google Scholar 

  10. Gai, S.A. & Wittrup, K.D. Curr. Opin. Struct. Biol. 17, 467–473 (2007).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Zeev Pancer is at the Center of Marine Biotechnology and Roy A. Mariuzza is at the Center for Advanced Research in Biotechnology, both Centers of the University of Maryland Biotechnology Institute, 701 East Pratt St., Baltimore, Maryland 21202, USA. pancer@comb.umbi.umd.edu,

    Zeev Pancer & Roy A Mariuzza

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  1. Zeev Pancer
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  2. Roy A Mariuzza
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Pancer, Z., Mariuzza, R. The oldest antibodies newly discovered. Nat Biotechnol 26, 402–403 (2008). https://doi.org/10.1038/nbt0408-402

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