Skip to main content
SpringerLink
Log in

Encoding technical information in GM organisms

  • Commentary
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: An artificial triplet-based code for specifying technical information in DNA.
Figure 2: An example of a technical information message shows a variable region flanked by conserved sequences (gray boxes).
Figure 3: One possible approach for upgrading the technical information message (conserved sequences, dark gray boxes; variable region, light gray boxes) consists of amplifying the entire plasmid with primers with 5′ extensions (shown in orange and green).

References

  1. Schiermeier, Q. Nature 409, 967 (2001).

    Article  CAS  Google Scholar 

  2. Dorey, E. Nat. Biotechnol. 19, 795 (2001).

    Article  CAS  Google Scholar 

  3. Pease, A.C. et al. Proc. Natl. Acad. Sci. USA 91, 5022–5026 (1994).

    Article  CAS  Google Scholar 

  4. Tilliv, S.V. & Mirzabekov, A.D. Curr. Opin. Biotechnol. 12, 53–58 (2001).

    Article  Google Scholar 

  5. Von Neumann, J. & Burks, A.W. Theory of Self-Reproducing Automata (Univ. of Illinois Press, Urbana, IL, 1966).

    Google Scholar 

  6. Thomas, R.F. (ed.) Virgil: The Georgics (Cambridge Univ. Press, Cambridge, 1988).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. senior scientist at Icon Genetics AG, Maximilianstr. 38/40, Munich, 80539, Germany

    Sylvestre Marillonnet

  2. research director at Icon Genetics AG, Maximilianstr. 38/40, Munich, 80539, Germany

    Victor Klimyuk

  3. chief executive officer at Icon Genetics AG, Maximilianstr. 38/40, Munich, 80539, Germany

    Yuri Gleba

Authors
  1. Sylvestre Marillonnet
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Victor Klimyuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuri Gleba
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yuri Gleba.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marillonnet, S., Klimyuk, V. & Gleba, Y. Encoding technical information in GM organisms. Nat Biotechnol 21, 224–226 (2003). https://doi.org/10.1038/nbt0303-224

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0303-224

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation