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Make or break for costimulatory blockers

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An Erratum to this article was published on 01 March 2004

An Erratum to this article was published on 29 February 2004

This article has been updated

Immunomodulator CTLA4-Ig was set to be the miracle drug for organ transplantation a dozen years ago, but then faded from view. Now, with startling results in rheumatoid arthritis, costimulatory blockers are on a comeback. Ken Garber reports.

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Figure 1: Structures of the interacting surfaces of complexes of CTLA-4 (cyan) and B7 (purple).
Figure 2: On the block.

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Garber, K. Make or break for costimulatory blockers. Nat Biotechnol 22, 145–147 (2004). https://doi.org/10.1038/nbt0204-145

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