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A backpack revs up T-cell activity

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Cytokine backpacks improve T-cell efficacy in the tumor microenvironment.

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Figure 1: IL-15 backpacks selectively enhance T-cell activity at tumors.

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Authors and Affiliations

  1. Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA

    Thomas Shum & Helen E Heslop

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  1. Thomas Shum
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  2. Helen E Heslop
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Correspondence to Helen E Heslop.

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Competing interests

T.S. is co-author on a patent application for constitutively active cytokine receptors for cell therapy.

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Shum, T., Heslop, H. A backpack revs up T-cell activity. Nat Biotechnol 36, 702–703 (2018). https://doi.org/10.1038/nbt.4215

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