Transplantation of cerebral organoids into the mouse brain overcomes some limitations of in vitro systems.
References
Lancaster, M.A. et al. Nature 501, 373–379 (2013).
Mansour, A.A. et al. Nat. Biotechnol. 36, 432–441 (2018).
DeFelipe, J. Front. Neuroanat. 5 (2011).
Kelava, I. & Lancaster, M.A. Cell Stem Cell 18, 736–748 (2016).
Kadoshima, T. et al. Proc. Natl. Acad. Sci. USA. 110, 20284–20289 (2013).
Lancaster, M.A. et al. Nat. Biotechnol. 35, 659–666 (2017).
Kilb, W., Kirischuk, S. & Luhmann, H.J. Eur. J. Neurosci. 34, 1677–1686 (2011).
Quadrato, G. et al. Nature 545, 48–53 (2017).
Takebe, T. et al. Nature 499, 481–484 (2013).
Smith, Q. & Gerecht, S. Curr. Opin. Chem. Eng. 3, 42–50 (2014).
van den Berg, C.W. et al. Stem Cell Rep. 10, 751–765 (2018).
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Lancaster, M. Brain organoids get vascularized. Nat Biotechnol 36, 407–408 (2018). https://doi.org/10.1038/nbt.4133
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DOI: https://doi.org/10.1038/nbt.4133
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