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Driving T-cell immunotherapy to solid tumors

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T cell receptor (TCR) gene therapy can target the immune system to solid tumors in ways CAR-T cells can't match, but the field is still looking for a clear success. Ken Garber reports.

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Figure 1: Dueling T-cell receptors.

References

  1. Yanagi, Y. et al. Nature 308, 145–149 (1984).

    Article  CAS  Google Scholar 

  2. Hedrick, S.M., Cohen, D.I., Nielsen, E.A. & Davis, M.M. Nature 308, 149–153 (1984).

    Article  CAS  Google Scholar 

  3. Dembić, Z. et al. Nature 320, 232–238 (1986).

    Article  Google Scholar 

  4. Morgan, R.A. et al. Science 314, 126–129 (2006).

    Article  CAS  Google Scholar 

  5. Holler, P.D. et al. Proc. Natl. Acad. Sci. USA 97, 5387–5392 (2000).

    Article  CAS  Google Scholar 

  6. Robbins, P.F. et al. J. Clin. Oncol. 29, 917–924 (2011).

    Article  Google Scholar 

  7. Parkhurst, M.R. et al. Mol. Ther. 19, 620–626 (2011).

    Article  CAS  Google Scholar 

  8. Morgan, R.A. et al. J. Immunother. 36, 133–151 (2013).

    Article  CAS  Google Scholar 

  9. Linette, G.P. et al. Blood 122, 863–871 (2013).

    Article  CAS  Google Scholar 

  10. Schmitt, T.M. et al. Blood 122, 348–356 (2013).

    Article  CAS  Google Scholar 

  11. Mackall, C. et al. J. Clin. Oncol. 35, suppl; abstr. 3000 (2017).

    Article  Google Scholar 

  12. Lu, Y.C. et al. Clin. Cancer Res. 20, 3401–3410 (2014).

    Article  CAS  Google Scholar 

  13. Tran, E. et al. Science 344, 641–645 (2014).

    Article  CAS  Google Scholar 

  14. Deniger, D.C. et al. Mol. Ther. 24, 1078–1089 (2016).

    Article  CAS  Google Scholar 

  15. Oda, S.K. et al. Blood 130, 2410–2419 (2017).

    Article  CAS  Google Scholar 

  16. Corrales, L., McWhirter, S.M., Dubensky, T.W. Jr. & Gajewski, T.F. J. Clin. Invest. 126, 2404–2411 (2016).

    Article  Google Scholar 

  17. Roybal, K.T. et al. Cell 164, 770–779 (2016).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Ann Arbor, Michigan

    Ken Garber

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  1. Ken Garber
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Garber, K. Driving T-cell immunotherapy to solid tumors. Nat Biotechnol 36, 215–219 (2018). https://doi.org/10.1038/nbt.4090

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