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Generation of knockout mice by Cpf1-mediated gene targeting

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Figure 1: Generation of Cpf1-mediated Trp53 mutant mice.

References

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Acknowledgements

This study was supported by the Ministry of Science, ICT and Future Planning (MSIP) through the National Research Foundation of Korea (NRF) (2013R1A1A1009962, 2014M3A9D5A01073836, 2015R1A1A1A05001483). This work was also supported by a grant (2016-649) from the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea. We appreciate the technical assistance from the Genomics Core Laboratory of Asan Institute for Life Sciences.

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Authors and Affiliations

  1. Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

    Yongsub Kim & Myeong Sup Lee

  2. Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea

    Seung-A Cheong, Jong Geol Lee, In-Jeoung Baek & Young Hoon Sung

  3. College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea

    Jong Geol Lee

  4. Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

    Sang-Wook Lee

  5. Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea

    In-Jeoung Baek & Young Hoon Sung

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  1. Yongsub Kim
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  2. Seung-A Cheong
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  3. Jong Geol Lee
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  4. Sang-Wook Lee
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  5. Myeong Sup Lee
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  6. In-Jeoung Baek
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  7. Young Hoon Sung
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Corresponding authors

Correspondence to Sang-Wook Lee, Myeong Sup Lee, In-Jeoung Baek or Young Hoon Sung.

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The authors declare no competing financial interests.

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Editor's note: This article has been peer-reviewed.

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Supplementary Figures 1–10, Supplementary Tables 1–5 and Supplementary Methods (PDF 2686 kb)

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Kim, Y., Cheong, SA., Lee, J. et al. Generation of knockout mice by Cpf1-mediated gene targeting. Nat Biotechnol 34, 808–810 (2016). https://doi.org/10.1038/nbt.3614

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