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Precision and robustness of 2D-NMR for structure assessment of filgrastim biosimilars

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Figure 1: Spectral and statistical comparisons of NMR data.

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Authors and Affiliations

  1. Division of Pharmaceutical Analysis, US Food and Drug Administration, Center for Drug Evaluation and Research, St. Louis, Missouri, USA

    Houman Ghasriani, Lucinda F Buhse & David A Keire

  2. Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario, Canada

    Derek J Hodgson & Yves Aubin

  3. Institute for Bioscience and Biotechnology Research, National Institute of Standards and Technology, Rockville, Maryland, USA

    Robert G Brinson & John P Marino

  4. Medical Products Agency of Sweden, Uppsala, Sweden

    Ian McEwen

  5. US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Biotechnology Products, Silver Spring, Maryland, USA

    Steven Kozlowski

Authors
  1. Houman Ghasriani
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  2. Derek J Hodgson
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  3. Robert G Brinson
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  4. Ian McEwen
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  5. Lucinda F Buhse
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  6. Steven Kozlowski
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  7. John P Marino
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  8. Yves Aubin
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  9. David A Keire
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Corresponding authors

Correspondence to John P Marino, Yves Aubin or David A Keire.

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The authors declare no competing financial interests.

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Supplementary Figures 1–4, Supplementary Tables 1–12 and Supplementary Methods (PDF 2210 kb)

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Ghasriani, H., Hodgson, D., Brinson, R. et al. Precision and robustness of 2D-NMR for structure assessment of filgrastim biosimilars. Nat Biotechnol 34, 139–141 (2016). https://doi.org/10.1038/nbt.3474

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