Skip to main content
SpringerLink
Log in

Big thinking for adjuvants

  • News & Views
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

Particles formed by polymeric adjuvants preferentially localize to the lymph node and elicit robust immunity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Polymeric adjuvants are synthesized by conjugating a small-molecule TLR-7/8 agonist (TLR-7/8a) to a hydrophilic polymer backbone.

Marina Spence/Nature Publishing Group

References

  1. Lynn, G.M. et al. Nat. Biotechnol. 33, 1201–1210 (2015).

    Article  CAS  Google Scholar 

  2. Steinhagen, F., Kinjo, T., Bode, C. & Klinman, D.M. Vaccine 29, 3341–3355 (2011).

    Article  CAS  Google Scholar 

  3. Vasilakos, J.P. & Tomai, M.A. Expert Rev. Vaccines 12, 809–819 (2013).

    Article  CAS  Google Scholar 

  4. Kawai, T. & Akira, S. Immunity 34, 637–650 (2011).

    Article  CAS  Google Scholar 

  5. Lizée, G. et al. Annu. Rev. Med. 64, 71–90 (2013).

    Article  Google Scholar 

  6. Wu, T.Y. et al. Sci. Transl. Med. 6, 263ra160 (2014).

    Article  Google Scholar 

  7. Hanson, M.C. et al. J. Clin. Invest. 125, 2532–2546 (2015).

    Article  Google Scholar 

  8. Kopeček, J. & Kopečková, P. Adv. Drug Deliv. Rev. 62, 122–149 (2010).

    Article  Google Scholar 

  9. Park, H. et al. J. Immunol. 190, 4103–4115 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Eric L. Dane and Darrell J. Irvine are at the David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.,

    Eric L Dane & Darrell J Irvine

Authors
  1. Eric L Dane
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Darrell J Irvine
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Darrell J Irvine.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dane, E., Irvine, D. Big thinking for adjuvants. Nat Biotechnol 33, 1146–1148 (2015). https://doi.org/10.1038/nbt.3398

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.3398

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation