Skip to main content

Advertisement

SpringerLink
Log in

Drugging the gut microbiome

  • News Feature
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

An Erratum to this article was published on 09 May 2017

This article has been updated

Using conventional drug discovery and novel synthetic biology approaches, some investigators and companies are mining our resident microbes and their metabolites for targets in small-molecule drug programs. Ken Garber reports.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The metabolites produced by gut bacterial fermentation of dietary fiber induce Tregs and dampen inflammation.

Change history

  • 12 October 2016

    In the version of this article initially published, on p.231, left-hand column, the maker of linaclotide was said to be Redwood rather than Ironwood Pharmaceuticals. In addition, linaclotide is no longer referred to as a “homolog of the enterotoxin peptides,” but as “similar to the enterotoxin peptides,” and it has been clarified to be “rationally designed.” The errors have been corrected in the HTML and PDF versions of the article.

References

  1. Wang, Z. et al. Nature 472, 57–63 (2011).

    Article  CAS  Google Scholar 

  2. van Nood, E. et al. N. Engl. J. Med. 368, 407–415 (2013).

    Article  CAS  Google Scholar 

  3. Hsiao, E.Y. et al. Cell 155, 1451–1463 (2013).

    Article  CAS  Google Scholar 

  4. Mazmanian, S.K. et al. Cell 122, 107–118 (2005).

    Article  CAS  Google Scholar 

  5. Atarashi, K. et al. Nature 500, 232–236 (2013).

    Article  CAS  Google Scholar 

  6. Trompette, A. et al. Nat. Med. 20, 159–166 (2014).

    Article  CAS  Google Scholar 

  7. Chang, P.V. et al. Proc. Natl. Acad. Sci. USA 111, 2247–2252 (2014).

    Article  CAS  Google Scholar 

  8. Yoshimoto, S. et al. Nature 499, 97–101 (2013).

    Article  CAS  Google Scholar 

  9. Donia, M.S. et al. Cell 158, 1402–1414 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ann Arbor, Michigan

    Ken Garber

Authors
  1. Ken Garber
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Garber, K. Drugging the gut microbiome. Nat Biotechnol 33, 228–231 (2015). https://doi.org/10.1038/nbt.3161

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.3161

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation