Skip to main content
Log in

Making biology transparent

  • News & Views
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

The molecular and cellular architecture of the organs in a whole mouse is revealed through optical clearing.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Whole-organ clearing with perfusion-assisted agent release in situ.

Marina Corral Spence/Nature Publishing Group

References

  1. Chung, K. et al. Nature 497, 332–337 (2013).

    Article  CAS  Google Scholar 

  2. Yang, B. et al. Cell 158, 945–958 (2014).

    Article  CAS  Google Scholar 

  3. Becker, K., Jahrling, N., Saghafi, S., Weiler, R. & Dodt, H.U. PLoS ONE 7, e33916 (2012).

    Article  CAS  Google Scholar 

  4. Hama, H. et al. Nat. Neurosci. 14, 1481–1488 (2011).

    Article  CAS  Google Scholar 

  5. Ke, M.T., Fujimoto, S. & Imai, T. Nat. Neurosci. 16, 1154–1161 (2013).

    Article  CAS  Google Scholar 

  6. Tomer, R., Ye, L., Hsueh, B. & Deisseroth, K. Nat. Protoc. 9, 1682–1697 (2014).

    Article  CAS  Google Scholar 

  7. Keller, P.J. & Dodt, H.U. Curr. Opin. Neurobiol. 22, 138–143 (2012).

    Article  CAS  Google Scholar 

  8. Susaki, E.A. et al. Cell 157, 726–739 (2014).

    Article  CAS  Google Scholar 

  9. Wang, J., Shi, R. & Zhu, D. J. Biomed. Opt. 18, 061209 (2013).

    Article  Google Scholar 

  10. Spalteholz, W. Über das Durchsichtigmachen von menschlichen und tierischen Präparaten. (S. Hirzel, Leipzig; 1914).

    Google Scholar 

  11. Dent, J.A., Polson, A.G. & Klymkowsky, M.W. Development 105, 61–74 (1989).

    CAS  PubMed  Google Scholar 

  12. Kuwajima, T. et al. Development 140, 1364–1368 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Burkhard Höckendorf, Luke D Lavis or Philipp J Keller.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Höckendorf, B., Lavis, L. & Keller, P. Making biology transparent. Nat Biotechnol 32, 1104–1105 (2014). https://doi.org/10.1038/nbt.3061

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.3061

  • Springer Nature America, Inc.

This article is cited by

Navigation