Reducing the glycan heterogeneity of recombinant proteins may improve the efficacy of biopharmaceuticals.
References
Lepenies, B., Yin, J. & Seeberger, P.H. Curr. Opin. Chem. Biol. 14, 404–411 (2010).
Meuris, L. et al. Nat. Biotechnol. 32, 485–487 (2014).
Rich, J.R. & Withers, S.G. Nat. Chem. Biol. 5, 206–215 (2009).
Schwarz, F. et al. Nat. Chem. Biol. 6, 264–266 (2010).
Hamilton, S.R. et al. Science 313, 1441–1443 (2006).
Castilho, A. et al. Glycobiology 21, 813–823 (2011).
Aumiller, J.J., Mabashi-Asazuma, H., Hillar, A., Shi, X. & Jarvis, D.L. Glycobiology 22, 417–428 (2012).
Wang, Z. et al. Science 341, 379–383 (2013).
Wang, P. et al. Science 342, 1357–1360 (2013).
Seeberger, P.H. & Werz, D.B. Nature 446, 1046–1051 (2007).
Reeves, P.J., Callewaert, N., Contreras, R. & Khorana, H.G. Proc. Natl. Acad. Sci. USA 99, 13419–13424 (2002).
Lepenies, B., Lee, J. & Sonkaria, S. Adv. Drug Deliv. Rev. 65, 1271–1281 (2013).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Lepenies, B., Seeberger, P. Simply better glycoproteins. Nat Biotechnol 32, 443–445 (2014). https://doi.org/10.1038/nbt.2893
Published:
Issue Date:
DOI: https://doi.org/10.1038/nbt.2893
- Springer Nature America, Inc.