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Next-generation sequencing in the clinic

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Pools of cell lines carrying a variety of known mutations are used to validate the performance of a cancer diagnostic test based on next-generation sequencing.

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Figure 1: Clinical sequencing test protocol and validation.

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Authors and Affiliations

  1. Jason Y. Park is at the Department of Pathology, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, Texas, USA, and the Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA.,

    Jason Y Park

  2. Larry J. Kricka is at the Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA.,

    Larry J Kricka

  3. Department of Cancer Biology, Paolo Fortina is at the Cancer Genomics Laboratory, Kimmel Cancer Center, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania, USA.,

    Paolo Fortina

Authors
  1. Jason Y Park
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  2. Larry J Kricka
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  3. Paolo Fortina
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Corresponding author

Correspondence to Jason Y Park.

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The authors declare no competing financial interests.

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Park, J., Kricka, L. & Fortina, P. Next-generation sequencing in the clinic. Nat Biotechnol 31, 990–992 (2013). https://doi.org/10.1038/nbt.2743

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