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The regulatory landscape for actively personalized cancer immunotherapies

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Figure 1: Three levels of personalization in cancer immunotherapies.

References

  1. Sjoblom, T. et al. Science 314, 268–274 (2006).

    Article  Google Scholar 

  2. Gerlinger, M. et al. N. Engl. J. Med. 366, 883–892 (2012).

    Article  CAS  Google Scholar 

  3. Castle, J.C. et al. Cancer Res. 72, 1081–1091 (2012).

    Article  CAS  Google Scholar 

  4. Matsushita, H. et al. Nature 482, 400–404 (2012).

    Article  CAS  Google Scholar 

  5. Robbins, P.F. et al. Nat. Med. 19, 747–752 (2013).

    Article  CAS  Google Scholar 

  6. van Rooij, N. et al. J. Clin. Oncol. doi:10.1200/jco.2012.47.7521 (16 September 2013).

  7. Vonderheide, R.H. et al. Nat. Med. 19, 1098–1100 (2013).

    Article  CAS  Google Scholar 

  8. Terasaki, M. et al. J. Clin. Oncol. 29, 337–344 (2011).

    Article  CAS  Google Scholar 

  9. Noguchi, M. et al. Prostate 72, 834–845 (2012).

    Article  CAS  Google Scholar 

  10. Carbone, D.P. et al. J. Clin. Oncol. 23, 5099–5107 (2005).

    Article  Google Scholar 

  11. Rahma, O.E. et al. J. Transl. Med. 8, 8 (2010).

    Article  Google Scholar 

  12. Lifton, R.P. N. Engl. J. Med. 362, 1235–1236 (2010).

    Article  CAS  Google Scholar 

  13. Rammensee, H.G. et al. Immunogenetics 41, 178–228 (1995).

    Article  CAS  Google Scholar 

  14. Weinschenk, T. et al. Cancer Res. 62, 5818–5827 (2002).

    CAS  PubMed  Google Scholar 

  15. European Medicines Agency. Guideline on Strategies to Identify and Mitigate Risks for First-in-Human Clinical Trials with Investigational Medicinal Products CHMP/SWP/28367/07; http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002988.pdf (EMA, London, 2007).

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Acknowledgements

U.K. participated on behalf of the CIMT Regulatory Research Group. Twincore, Centre for Experimental and Clinical Infection Research, is a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.

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Author notes

  1. Cedrik M Britten and Harpreet Singh-Jasuja: These authors contributed equally to this work.

  2. Thomas Hinz and Ulrich Kalinke: These authors jointly supervised this work.

Authors and Affiliations

  1. TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gGmbH, Mainz, Germany

    Cedrik M Britten, Sebastian Kreiter & Ugur Sahin

  2. Ribological GmbH, Mainz, Germany

    Cedrik M Britten

  3. Immatics Biotechnologies GmbH, Tübingen, Germany

    Harpreet Singh-Jasuja

  4. URPhyM, NARILIS, University of Namur, Namur, Belgium

    Bruno Flamion

  5. GlaxoSmithKline, Collegeville, Pennsylvania, USA

    Axel Hoos

  6. Association for Cancer Immunotherapy, Mainz, Germany

    Christoph Huber

  7. Curevac GmbH, Tübingen, Germany

    Karl-Josef Kallen

  8. Georgia Health Sciences University Cancer Center, Augusta, Georgia, USA

    Samir N Khleif

  9. Celldex Therapeutics Inc., Needham, Massachusetts, USA

    Michaela Nielsen

  10. University of Tübingen, Tübingen, Germany

    Hans-Georg Rammensee

  11. BioNTech AG, Mainz, Germany

    Ugur Sahin

  12. Paul-Ehrlich-Institut, Langen, Germany

    Thomas Hinz

  13. Twincore, Centre for Experimental and Clinical Infection Research, Hannover, Germany

    Ulrich Kalinke

Authors
  1. Cedrik M Britten
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  2. Harpreet Singh-Jasuja
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  3. Bruno Flamion
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  4. Axel Hoos
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  5. Christoph Huber
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  6. Karl-Josef Kallen
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  7. Samir N Khleif
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  8. Sebastian Kreiter
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  9. Michaela Nielsen
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  10. Hans-Georg Rammensee
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  11. Ugur Sahin
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  12. Thomas Hinz
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  13. Ulrich Kalinke
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Corresponding author

Correspondence to Ulrich Kalinke.

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Competing interests

H.S.-J. is employee and shareholder of Immatics Biotechnologies GmbH, which has a commercial interest in development of cancer immunotherapies.

C.H. is co-founder, advisor and deputy-chairman of BioNTech. BioNTech develops highly individualized mutational epitope tumor vaccines.

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Britten, C., Singh-Jasuja, H., Flamion, B. et al. The regulatory landscape for actively personalized cancer immunotherapies. Nat Biotechnol 31, 880–882 (2013). https://doi.org/10.1038/nbt.2708

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