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Compartmentalizing metabolic pathways in organelles

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The entire metabolic pathway for producing a biofuel is confined within a yeast organelle to increase yield over the endogenous pathway split between two compartments.

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Figure 1: Eukaryotic organelles offer multiple environments distinct from the cytosol that may be attractive for engineering metabolism.

References

  1. Farhi, M. et al. Metab. Eng. 13, 474–481 (2011).

    Article  CAS  Google Scholar 

  2. Bayer, T.S. et al. J. Am. Chem. Soc. 131, 6508–6515 (2009).

    Article  CAS  Google Scholar 

  3. Avalos, J.L., Fink, G.R. & Stephanopoulos, G. Nat. Biotechnol. 31, 335–341 (2013).

    Article  CAS  Google Scholar 

  4. Atsumi, S., Hanai, T. & Liao, J.C. Nature 451, 86–89 (2008).

    Article  CAS  Google Scholar 

  5. Brat, D., Weber, C., Lorenzen, W., Bode, H.B. & Boles, E. Biotechnol. Biofuels 5, 65 (2012).

    Article  CAS  Google Scholar 

  6. Chen, X., Nielsen, K.F., Borodina, I., Kielland-Brandt, M.C. & Karhumaa, K. Biotechnol. Biofuels 4, 21 (2011).

    Article  CAS  Google Scholar 

  7. Kondo, T. et al. J. Biotechnol. 159, 32–37 (2012).

    Article  CAS  Google Scholar 

  8. Martín, D., Piulachs, M.-D., Cunillera, N., Ferrer, A. & Bellés, X. Biochim. Biophys. Acta 1773, 419–426 (2007).

    Article  Google Scholar 

  9. Denoncin, K. & Collet, J.-F. Antioxid. Redox Signal. published online, doi:10.1089/ars.2012.4864 (2 October 2012).

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Authors and Affiliations

  1. William C. DeLoache and John E. Dueber are at the Energy Biosciences Building, University of California, Berkeley, California, USA.,

    William C DeLoache & John E Dueber

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  1. William C DeLoache
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  2. John E Dueber
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Correspondence to John E Dueber.

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The authors declare no competing financial interests.

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DeLoache, W., Dueber, J. Compartmentalizing metabolic pathways in organelles. Nat Biotechnol 31, 320–321 (2013). https://doi.org/10.1038/nbt.2549

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