Skip to main content

Advertisement

SpringerLink
Log in

Transforming lymph nodes into tissue factories

  • News & Views
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

Transplanting donor cells into lymph nodes regenerates liver, pancreas and thymus function in mice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Generation of ectopic liver, pancreatic islets and thymus by lymph node transplantation.

Marina Corral

References

  1. Berthiaume, F., Maguire, T.J. & Yarmush, M.L. Annu. Rev. Chem. Biomol. Eng. 2, 403–430 (2011).

    Article  Google Scholar 

  2. Komori, et al. Nat. Biotechnol. 30, 976–983 (2012).

    Article  CAS  Google Scholar 

  3. Uygun, B.E. et al. Nat. Med. 16, 814–820 (2010).

    Article  CAS  Google Scholar 

  4. Rodewald, H.R. Curr. Top. Microbiol. Immunol. 251, 101–108 (2000).

    CAS  PubMed  Google Scholar 

  5. Gill, J., Malin, M., Holländer, G.A. & Boyd, R. Nat. Immunol. 3, 635–642 (2002).

    Article  CAS  Google Scholar 

  6. Seach, N. et al. Tissue Eng. Part C Methods 16, 543–551 (2010).

    Article  CAS  Google Scholar 

  7. Markert, M.L., Devlin, B.H. & McCarthy, E.A. Clin. Immunol. 135, 236–246 (2010).

    Article  CAS  Google Scholar 

  8. Poznansky, M.C. et al. Nat. Biotechnol. 18, 729–734 (2000).

    Article  CAS  Google Scholar 

  9. Clark, R.A., Yamanaka, K., Bai, M., Dowgiert, R. & Kupper, T.S. J. Clin. Invest. 115, 3239–3249 (2005).

    Article  CAS  Google Scholar 

  10. Hoppo, T., Komori, J., Manohar, R., Stolz, D.B. & Lagasse, E. Gastroenterology 140, 656–666 (2011).

    Article  CAS  Google Scholar 

  11. Terra, R. et al. Blood 106, 193–200 (2005).

    Article  CAS  Google Scholar 

  12. Maillard, I. et al. Blood 107, 3511–3519 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Johannes L. Zakrzewski, Andrea Z. Tuckett and Marcel R. M. van den Brink are at the Memorial Sloan-Kettering Cancer Center, New York, New York, USA.,

    Johannes L Zakrzewski, Andrea Z Tuckett & Marcel R M van den Brink

Authors
  1. Johannes L Zakrzewski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrea Z Tuckett
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marcel R M van den Brink
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marcel R M van den Brink.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zakrzewski, J., Tuckett, A. & van den Brink, M. Transforming lymph nodes into tissue factories. Nat Biotechnol 30, 958–959 (2012). https://doi.org/10.1038/nbt.2388

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.2388

  • Springer Nature America, Inc.

Search

Navigation