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Knockout rats generated by embryo microinjection of TALENs

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Figure 1: Design and assay of TALENs that target rat IgM locus.

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Authors and Affiliations

  1. INSERM UMR 643, Nantes, France

    Laurent Tesson, Claire Usal, Séverine Ménoret, Séverine Remy & Ignacio Anegon

  2. Platform Transgenic Rats Nantes IBiSA-CNRS, CHU Nantes, Nantes

    Laurent Tesson, Claire Usal, Séverine Ménoret, Séverine Remy & Ignacio Anegon

  3. Université de Nantes,

    Laurent Tesson, Claire Usal, Séverine Ménoret, Séverine Remy & Ignacio Anegon

  4. Sangamo Biosciences, Richmond, California, USA

    Elo Leung, Brett J Niles, Yolanda Santiago, Anna I Vincent, Xiangdong Meng, Lei Zhang, Philip D Gregory & Gregory J Cost

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  1. Laurent Tesson
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  2. Claire Usal
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  3. Séverine Ménoret
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  8. Anna I Vincent
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  9. Xiangdong Meng
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  11. Philip D Gregory
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  12. Ignacio Anegon
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Corresponding authors

Correspondence to Ignacio Anegon or Gregory J Cost.

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Competing interests

E.L., B.J.N., Y.S., A.I.V., X.M., L.Z., P.D.G, and G.J.C. are employees of Sangamo BioSciences. Sangamo BioSciences provided financial support for research in I.A.'s laboratory. Sangamo BioSciences has filed a patent application on the basis of these results.

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Supplementary Figures 1–3, Supplementary Tables 1–4, Supplementary Sequences and Supplementary Methods (PDF 5808 kb)

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Tesson, L., Usal, C., Ménoret, S. et al. Knockout rats generated by embryo microinjection of TALENs. Nat Biotechnol 29, 695–696 (2011). https://doi.org/10.1038/nbt.1940

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