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A new look at membrane protein binding

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An optical spectroscopy method can measure the affinities of ligands to membrane receptors that are embedded in their native membranes.

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References

  1. Baksh, M.M. et al. Nat Biotechnol. 29, 357–360 (2011).

    Article  CAS  Google Scholar 

  2. Tilakaratne, N. & Sexton, P.M. Clin. Exp. Pharmacol. Physiol. 32, 979–987 (2005).

    Article  CAS  Google Scholar 

  3. Smith, N.J. & Milligan, G. Pharmacol. Rev. 62, 701–725 (2010).

    Article  CAS  Google Scholar 

  4. Keiser, M.J. et al. Biochemistry 49, 10267–10276 (2010).

    Article  CAS  Google Scholar 

  5. Schröder, R. et al. Nat. Biotechnol. 28, 943–949 (2010).

    Article  Google Scholar 

  6. Whitehurst, C.E. & Annis, D.A. Comb. Chem. High Throughput Screen. 11, 427–438 (2008).

    Article  CAS  Google Scholar 

  7. Dodgson, K. et al. J. Recept. Signal Transduct. Res. 29, 163–172 (2009).

    Article  CAS  Google Scholar 

  8. Kussrow, A. et al. Chembiochem. published online, doi:10.1002/cbic.201000671 (29 December 2010).

  9. Conn, P.J. et al. Nat. Rev. Drug Discov. 8, 41–54 (2009).

    Article  CAS  Google Scholar 

  10. Eglen, R. & Reisine, T. Assay Drug Dev. Technol. published online, doi:10.1089/adt.2010.0305 (27 December 2010).

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The author is employed by Merck Sharp and Dohme Corp.

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Lunn, C. A new look at membrane protein binding. Nat Biotechnol 29, 328–329 (2011). https://doi.org/10.1038/nbt.1820

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