An optical spectroscopy method can measure the affinities of ligands to membrane receptors that are embedded in their native membranes.
References
Baksh, M.M. et al. Nat Biotechnol. 29, 357–360 (2011).
Tilakaratne, N. & Sexton, P.M. Clin. Exp. Pharmacol. Physiol. 32, 979–987 (2005).
Smith, N.J. & Milligan, G. Pharmacol. Rev. 62, 701–725 (2010).
Keiser, M.J. et al. Biochemistry 49, 10267–10276 (2010).
Schröder, R. et al. Nat. Biotechnol. 28, 943–949 (2010).
Whitehurst, C.E. & Annis, D.A. Comb. Chem. High Throughput Screen. 11, 427–438 (2008).
Dodgson, K. et al. J. Recept. Signal Transduct. Res. 29, 163–172 (2009).
Kussrow, A. et al. Chembiochem. published online, doi:10.1002/cbic.201000671 (29 December 2010).
Conn, P.J. et al. Nat. Rev. Drug Discov. 8, 41–54 (2009).
Eglen, R. & Reisine, T. Assay Drug Dev. Technol. published online, doi:10.1089/adt.2010.0305 (27 December 2010).
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Lunn, C. A new look at membrane protein binding. Nat Biotechnol 29, 328–329 (2011). https://doi.org/10.1038/nbt.1820
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DOI: https://doi.org/10.1038/nbt.1820
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