Skip to main content
SpringerLink
Log in

Lens regeneration in children

  • Brief Communications Arising
  • Published:

From Nature

View current issue Submit your manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Wu, X ., Long, E ., Lin, H. & Liu, Y. Prevalence and epidemiological characteristics of congenital cataract: a systematic review and meta-analysis. Sci. Rep. 6, 28564 (2016)

    Article  ADS  PubMed  PubMed Central  Google Scholar 

  2. Lambert, S. R . et al. Is there a latent period for the surgical treatment of children with dense bilateral congenital cataracts? J. AAPOS 10, 30–36 (2006)

    Article  PubMed  Google Scholar 

  3. Young, M. P ., Heidary, G. & VanderVeen, D. K. Relationship between the timing of cataract surgery and development of nystagmus in patients with bilateral infantile cataracts. J. AAPOS 16, 554–557 (2012)

    Article  PubMed  Google Scholar 

  4. Sukhija, J ., Ram, J ., Gupta, N ., Sawhney, A. & Kaur, S. Long-term results after primary intraocular lens implantation in children operated less than 2 years of age for congenital cataract. Indian J. Ophthalmol. 62, 1132–1135 (2014)

    Article  PubMed  PubMed Central  Google Scholar 

  5. Lin, H . et al. Lens regeneration using endogenous stem cells with gain of visual function. Nature 531, 323–328 (2016); corrigendum 541, 558 (2017)

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  6. Cvekl, A. & Ashery-Padan, R. The cellular and molecular mechanisms of vertebrate lens development. Development 141, 4432–4447 (2014)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Piatigorsky, J. Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation 19, 134–153 (1981)

    Article  CAS  PubMed  Google Scholar 

  8. Augusteyn, R. C. On the growth and internal structure of the human lens. Exp. Eye Res. 90, 643–654 (2010)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Hanna, C. & O’Brien, J. E. Cell production and migration in the epithelial layer of the lens. Arch. Ophthalmol. 66, 103–107 (1961)

    Article  CAS  PubMed  Google Scholar 

  10. Harding, C. V ., Hughes, W. L ., Bond, V. P. & Schork, P. Autoradiographic localization of tritiated thymidine in wholemount preparations of lens epithelium. Arch. Ophthalmol. 63, 58–65 (1960)

    Article  CAS  PubMed  Google Scholar 

  11. Mikulicich, A. G. & Young, R. W. Cell proliferation and displacement in the lens epithelium of young rats injected with tritiated thymidine. Invest. Ophthalmol. 2, 344–354 (1963)

    CAS  PubMed  Google Scholar 

  12. Šikic´, H ., Shi, Y ., Lubura, S. & Bassnett, S. A stochastic model of eye lens growth. J. Theor. Biol. 376, 15–31 (2015)

    Article  MathSciNet  PubMed  PubMed Central  Google Scholar 

  13. Smith, P. Diseases of crystalline lens and capsule. 1. On the growth of the crystalline lens. Trans. Ophthalmol. Soc. UK 3, 79–99 (1883)

    ADS  Google Scholar 

  14. Miyake, K ., Ota, I ., Miyake, S. & Horiguchi, M. Liquefied aftercataract: a complication of continuous curvilinear capsulorhexis and intraocular lens implantation in the lens capsule. Am. J. Ophthalmol. 125, 429–435 (1998)

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA

    Demetrios G. Vavvas, Ankoor Shah, Ula Jurkunas, Roberto Pineda, Vasiliki Poulaki, David G. Hunter, Louis R. Pasquale, Joan W. Miller & Deborah VanderVeen

  2. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Demetrios G. Vavvas, Ula Jurkunas, Roberto Pineda, Louis R. Pasquale & Joan W. Miller

  3. Department of Ophthalmology, Ocular Pathology Service, Massachusetts Eye and Ear Infirmary ,Harvard Medical School, Boston, Massachusetts, USA

    Thaddeus P. Dryja

  4. Albert Florens Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA

    M. Edward Wilson

  5. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA

    Timothy W. Olsen

  6. Department of Ophthalmology, Boston Children’s Hospital, Boston, Massachusetts, USA

    Ankoor Shah, David G. Hunter & Deborah VanderVeen

  7. Department of Ophthalmology, Veterans Affairs Hospital, Boston University, Boston, Massachusetts, USA

    Vasiliki Poulaki

  8. Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA

    Sotiria Palioura

  9. Department of Ophthalmology, University of Chicago, Chicago, Illinois, USA

    Peter Veldman & Kathryn Colby

  10. Department of Ophthalmology, University of Navarra, Pamplona, Spain

    Javier Moreno-Montañés

  11. Ophthalmic Research Unit “Santiago Grisolía” and Cellular and Molecular Ophthalmobiology Group at the Department of Ophthalmology, University of Valencia, Valencia, Spain

    Maria D. Pinazo-Duran

  12. Department of Ophthalmology, Hospital Clinico Universitario and IOBA (Eye Institute) University of Valladolid, Valladolid, Spain

    José Carlos Pastor

  13. Department of Ophthalmology, University of Crete, Crete, Greece

    Miltiadis Tsilimbaris

  14. Department of Ophthalmology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Douglas Rhee

  15. Institute of Experimental Ophthalmology, Westfalian Wilhelms-University of Münster, Albert-Schweitzer Campus 1, Münster, D15, 48149, Germany

    Solon Thanos

  16. Department of Ophthalmology, Kagoshima University, Kagoshima, Japan

    Taiji Sakamoto

  17. Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, USA

    Scott R. Lambert

Authors
  1. Demetrios G. Vavvas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thaddeus P. Dryja
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Edward Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Timothy W. Olsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ankoor Shah
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ula Jurkunas
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Roberto Pineda
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Vasiliki Poulaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Sotiria Palioura
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Peter Veldman
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Javier Moreno-Montañés
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Maria D. Pinazo-Duran
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. José Carlos Pastor
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Miltiadis Tsilimbaris
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Douglas Rhee
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Kathryn Colby
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. David G. Hunter
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Solon Thanos
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Taiji Sakamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Louis R. Pasquale
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Joan W. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Deborah VanderVeen
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. Scott R. Lambert
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

D.G.V., T.P.D., M.E.W., T.W.O., L.R.P., J.W.M., D.V. and S.R.L. conceived, wrote and edited the manuscript. A.S., U.J., R.P., V.P., S.P., P.V., J.M.-M., M.D.P.-D., J.C.P., M.T., D.R., K.C., D.G.H., S.T. and T.S. reviewed and edited the manuscript.

Corresponding authors

Correspondence to Demetrios G. Vavvas, M. Edward Wilson, Timothy W. Olsen, José Carlos Pastor, Louis R. Pasquale, Joan W. Miller, Deborah VanderVeen or Scott R. Lambert.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vavvas, D., Dryja, T., Wilson, M. et al. Lens regeneration in children. Nature 556, E2–E3 (2018). https://doi.org/10.1038/nature26149

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature26149

  • Springer Nature Limited

This article is cited by

Search

Navigation