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Bacteria disarm host-defence proteins

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Infection with Shigella flexneri bacteria is a major cause of infant death. It emerges that S. flexneri evades intracellular defences by releasing a protein that triggers the destruction of members of a key family of host enzymes. See Letter p.378

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Figure 1: A bacterial protein triggers destruction of host proteins involved in immune defence.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and the Systems Biology Institute, Yale University, West Haven, 06477, Connecticut, USA

    John D. MacMicking

  2. Departments of Microbial Pathogenesis and Immunobiology, Yale University School of Medicine,

    John D. MacMicking

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  1. John D. MacMicking
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Correspondence to John D. MacMicking.

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MacMicking, J. Bacteria disarm host-defence proteins. Nature 551, 303–304 (2017). https://doi.org/10.1038/nature24157

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