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Zapping viral RNAs

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The discovery that the host defence protein ZAP specifically targets viral RNAs that are rich in a particular pair of adjacent bases — cytosine followed by guanine — sheds light on the evolution of viral RNA genomes. See Letter p.124

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Figure 1: ZAP protein selectively binds and blocks specific RNA viruses.

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References

  1. Atkinson, N. J., Witteveldt, J., Evans, D. J. & Simmonds, P. Nucleic Acids Res. 42, 4527–4545 (2014).

    Article  CAS  Google Scholar 

  2. Burns, C. C. et al. J. Virol. 83, 9957–9969 (2009).

    Article  CAS  Google Scholar 

  3. Cooper, D. N. & Gerber-Huber, S. Cell Differ. 17, 199–205 (1985).

    Article  CAS  Google Scholar 

  4. Tulloch, F., Atkinson, N. J., Evans, D. J., Ryan, M. D. & Simmonds, P. eLife 3, e04531 (2014).

    Article  Google Scholar 

  5. Takata, M. A. et al. Nature 550, 124–127 (2017).

    Article  ADS  CAS  Google Scholar 

  6. Gao, G., Guo, X. & Goff, S. P. Science 297, 1703–1706 (2002).

    Article  ADS  CAS  Google Scholar 

  7. Guo, X., Carroll, J. W., Macdonald, M. R., Goff, S. P. & Gao, G. J. Virol. 78, 12781–12787 (2004).

    Article  CAS  Google Scholar 

  8. Guo, X., Ma, J., Sun, J. & Gao, G. Proc. Natl Acad. Sci. USA 104, 151–156 (2007).

    Article  ADS  CAS  Google Scholar 

  9. Liu, C. H., Zhou, L., Chen, G. & Krug, R. M. Proc. Natl Acad. Sci. USA 112, 14048–14053 (2015).

    Article  ADS  CAS  Google Scholar 

  10. Tang, Q., Wang, X. & Gao, G. J. Virol. 91, e01909-16 (2017).

    Article  Google Scholar 

  11. Su, C., Zhang, J. & Zheng, C. Virol. J. 12, 203 (2015).

    Article  Google Scholar 

  12. Chen, S. et al. Nature Struct. Mol. Biol. 19, 430–435 (2012).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. the Departments of Biochemistry and Molecular Biophysics, and of Microbiology and Immunology, and at the Howard Hughes Medical Institute, Columbia University, New York, 10032, New York, USA

    Stephen P. Goff

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  1. Stephen P. Goff
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Correspondence to Stephen P. Goff.

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Goff, S. Zapping viral RNAs. Nature 550, 46–47 (2017). https://doi.org/10.1038/nature24140

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