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A toxin that fuels metabolism

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Formaldehyde, a DNA-damaging agent formed in cells, has now been shown to support metabolic processes that involve molecular units containing a single carbon atom — linking metabolism to a DNA-protection mechanism. See Article p.549

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Figure 1: Formaldehyde fuels one-carbon metabolism.

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Authors and Affiliations

  1. Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke University, Durham, 27710, North Carolina, USA

    Xiaojing Liu & Jason W. Locasale

Authors
  1. Xiaojing Liu
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  2. Jason W. Locasale
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Correspondence to Jason W. Locasale.

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Liu, X., Locasale, J. A toxin that fuels metabolism. Nature 548, 533–534 (2017). https://doi.org/10.1038/nature23541

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