Skip to main content

Advertisement

SpringerLink
Log in

Cancer

Precision T-cell therapy targets tumours

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

The T cells of the immune system can destroy tumours, but their activation can be inefficient. Vaccines that exploit tumour mutations elicit robust T-cell responses to tumours, with potential clinical benefits. See Letters p.217 & p.222

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Manipulating the immune response to tumours.

Notes

  1. See all news & views

References

  1. Pitt, J. M. et al. Ann. Oncol. 27, 1482–1492 (2016).

    Article  CAS  Google Scholar 

  2. Naidoo, J. et al. Ann. Oncol. 26, 2375–2391 (2015).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Castle, J. C. et al. Cancer Res. 72, 1081–1091 (2012).

    Article  CAS  Google Scholar 

  4. Gubin, M. M. et al. Nature 515, 577–581 (2014).

    Article  ADS  CAS  Google Scholar 

  5. Carreno, B. M. et al. Science 348, 803–808 (2015).

    Article  ADS  CAS  Google Scholar 

  6. Ott, P. et al. Nature 547, 217–221 (2017).

    Article  ADS  CAS  Google Scholar 

  7. Sahin, U. et al. Nature 547, 222–226 (2017).

    Article  ADS  CAS  Google Scholar 

  8. van der Burg, S. H., Arens, R., Ossendorp, F., van Hall, T. & Melief, C. J. Nature Rev. Cancer 16, 219–233 (2016).

    Article  CAS  Google Scholar 

  9. Szczepaniak Sloane, R. A. et al. Cancer 123, 2130–2142 (2017).

    Article  Google Scholar 

  10. Kreiter, S. et al. Cancer Res. 70, 9031–9040 (2010).

    Article  CAS  Google Scholar 

  11. Hirschhorn-Cymerman, D. et al. J. Exp. Med. 209, 2113–2126 (2012).

    Article  CAS  Google Scholar 

  12. Haabeth, O. A. et al. Leukemia 30, 1216–1220 (2016).

    Article  CAS  Google Scholar 

  13. Schoenberger, S. P., Toes, R. E., van der Voort, E. I., Offringa, R. & Melief, C. J. Nature 393, 480–483 (1998).

    Article  ADS  CAS  Google Scholar 

  14. Janssen, E. M. et al. Nature 421, 852–856 (2003).

    Article  ADS  CAS  Google Scholar 

  15. Alexandrov, L. B. et al. Nature 500, 415–421 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, Leiden, The Netherlands

    Cornelis J. M. Melief

  2. ISA Pharmaceuticals, Leiden

    Cornelis J. M. Melief

Authors
  1. Cornelis J. M. Melief
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cornelis J. M. Melief.

Ethics declarations

Competing interests

The author declares competing financial interests. See go.nature.com/2sqtds6 for details.

Related links

Related links

Related links in Nature Research

Immunology: The patterns of T-cell target recognition

Immunology: T-cell tweaks to target tumours

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Melief, C. Precision T-cell therapy targets tumours. Nature 547, 165–167 (2017). https://doi.org/10.1038/nature23093

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature23093

  • Springer Nature Limited

This article is cited by

Search

Navigation